pI: 8.3029 |
Length (AA): 434 |
MW (Da): 51626 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_139999)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_IV006890 | peptidyl-prolyl cis-trans isomerase, putative |
Caenorhabditis elegans | CELE_T27D1.1 | Protein CYN-9 |
Neospora caninum | NCLIV_030640 | peptidyl-prolyl cis-trans isomerase, cyclophylin protein, putative |
Plasmodium berghei | PBANKA_1227200 | peptidyl-prolyl cis-trans isomerase, putative |
Plasmodium falciparum | PF3D7_0803000 | peptidyl-prolyl cis-trans isomerase |
Plasmodium knowlesi | PKNH_0115900 | peptidyl-prolyl cis-trans isomerase, putative |
Plasmodium vivax | PVX_093595 | peptidyl-prolyl cis-trans isomerase, putative |
Plasmodium yoelii | PY05631 | Drosophila melanogaster CG12343 gene product, putative |
Toxoplasma gondii | TGME49_229940 | cyclophilin, putative |
Theileria parva | TP03_0222 | peptidyl-prolyl cis-trans isomerase, putative |
Theileria parva | TP03_0221 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_536100 | ubiquitin-protein ligase bre-1, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_229940 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_229940 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.